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Synthesis
DOI: 10.1055/a-2705-5409
Paper

Aerobic oxidation of imidazolines to 2-arylimidazoles using CuSO4∙H2O as a catalyst

Mekhman S. Yusubov
1   Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russian Federation (Ringgold ID: RIN65078)
,
Kristina A. Myachina
1   Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russian Federation (Ringgold ID: RIN65078)
,
Artem V. Semenov
1   Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russian Federation (Ringgold ID: RIN65078)
2   Institute of Chemistry, Saint Petersburg State University Institute of Chemistry, Saint Petersburg, Russian Federation (Ringgold ID: RIN429028)
,
Matvey K. Shurikov
1   Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russian Federation (Ringgold ID: RIN65078)
,
Dmitry Dar'in
3   Department of Natural Compounds Chemistry, Saint-Petersburg State University, Saint-Petersburg, Russian Federation
,
Sergey V. Baykov
2   Institute of Chemistry, Saint Petersburg State University Institute of Chemistry, Saint Petersburg, Russian Federation (Ringgold ID: RIN429028)
,
Natalia S. Soldatova
1   Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russian Federation (Ringgold ID: RIN65078)
,
Pavel S. Postnikov
1   Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russian Federation (Ringgold ID: RIN65078)
4   -, FSBIS Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation (Ringgold ID: RIN104687)
› Author Affiliations
Supported by: Russian Science Foundation 21-73-20031-P
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Imidazoles are considered the merit heterocyclic moiety in medicinal chemistry and drug design. Here, we report the convenient method for the aerobic oxidation of imidazolines under mild conditions using cheap and available CuSO4 ·5H2O as the catalyst. The proposed method allows to prepare 2-arylimidazoles bearing electron-donating and withdrawing groups in good and quantitative yields. The developed procedure is applicable for the preparation of labile and oxidation-intolerant heterocyclic moieties.



Publication History

Received: 17 June 2025

Accepted after revision: 02 September 2025

Accepted Manuscript online:
22 September 2025

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